6/7/2023 0 Comments Texmacs media![]() CAR T cells in trials: recent achievements and challenges that remain in the production of modified T cells for clinical applications. Köhl U, Arsenieva S, Holzinger A, Abken H. Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. 2008 118:294–305.įraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, et al. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. 2015 7:273ra13.īerger C, Jensen MC, Lansdorp PM, Gough M, Elliott C, Riddell SR. In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells. 2011 17:1290–7.īiasco L, Scala S, Basso Ricci L, Dionisio F, Baricordi C, Calabria A, et al. A human memory T cell subset with stem cell-like properties. Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, et al. Automated manufacturing of potent CD20-directed chimeric antigen receptor T cells for clinical use. Lock D, Mockel-Tenbrinck N, Drechsel K, Barth C, Mauer D, Schaser T, et al. Prophylactic tocilizumab prior to anti-CD19 CAR-T cell therapy for non-hodgkin lymphoma. 2021 12:7200.Ĭaimi PF, Pacheco Sanchez G, Sharma A, Otegbeye F, Ahmed N, Rojas P, et al. Multiple site place-of-care manufactured anti-CD19 CAR-T cells induce high remission rates in B-cell malignancy patients. Maschan M, Caimi PF, Reese-Koc J, Sanchez GP, Sharma AA, Molostova O, et al. Cost of decentralized CAR T-cell production in an academic nonprofit setting. Ran T, Eichmüller SB, Schmidt P, Schlander M. Closed-system manufacturing of CD19 and dual-targeted CD20/19 chimeric antigen receptor T cells using the CliniMACS Prodigy device at an academic medical center. Zhu F, Shah N, Xu H, Schneider D, Orentas R, Dropulic B, et al. Automated manufacture of autologous CD19 CAR-T cells for treatment of non-hodgkin lymphoma. ![]() Jackson Z, Roe A, Sharma AA, Lopes FBTP, Talla A, Kleinsorge-Block S, et al. Acute myeloid leukaemia: challenges and real world data from India. Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, et al. Financial toxicity and implications for cancer care in the era of molecular and immune therapies. No free rides: management of toxicities of novel immunotherapies in ALL, including financial. Our data highlights the safety, efficacy, and reproducibility of the process for use in planned future clinical trials. Based on our analysis, the cost per product would be approximately $35,107 US dollars. Evaluation of production costs in an academic, not for profit setting in India provide a benchmark for low and middle-income pricing which could greatly increase access to this therapy. The median transduction efficiency was 48.8%, with a median viability of 98% and fulfillment of all standard release criteria assays for clinical application. Validation run data, as part of a pre-clinical trial safety evaluation, demonstrates the successful and robust manufacturing of anti-CD19 CAR-T cells with T cell expansion of 25 to 47-fold. ![]() Here we demonstrate a decentralized manufacturing process for anti-CD19-CAR-T cells using a fully automated closed system (Miltenyi CliniMACS Prodigy®) is feasible in a developing country setting. Decentralized or point of care manufacturing has the potential to overcome some of these challenges. However, the high cost of existing industry-driven centralized production makes this therapy unaffordable in low and middle-income countries. Chimeric Antigen Receptor (CAR) T cell therapy is an accepted standard of care for relapsed/refractory B cell malignancies.
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6/7/2023 0 Comments Nomacs vs irfanviewBut this happens because developers go deep into these details, so should you. these set of functions should be undertandable for users without even thinking about it. Please test other image viewers and you will see that it usually is very easy to pan / navigate / scroll etc. It inearl feels like you added an anti-feature to the software on urpose to make people avoid using it, it is something where people get crazy asking "how can a developer not understand that?". It is an example for a good software that unfortunately fails in delivering totally expected very basic function and makes it very hard to try it a second time because the "very basic" category does not work as expected. This behavior can be configured in nomacs too.Ĭan confirm that first experience of nomacs made me conclude "not usable" because of not finding a way to pan the picture neither by keyboard or by mouse and not finding any hint about keyboard shortcuts and no way to configure these absolutely basic functions. ) use the mouse wheel for switching between images. Most image viewers I know (including IrfanView, Windows Photo Viewer. ![]() However for image viewers this is not the case (the mouse wheel would do nothing if the image fits the window). to scroll using the mouse wheel since their content is mostly vertical. The thing here is, that it makes sense for text editors etc. Let's call it mouse wheel : ) - Take a look at Google Maps - it has a pretty similar zoom/pan behavior as nomacs and is used by a lot of users.Ĭonform with the universal conventions on mouse wheel bindings listed above, and That's why it's called a scroll wheel not a zoom wheel -) For example placing the back button at the top left corner is extremely common - still it's not a good practice since this corner is hard to reach.Īlmost all users will expect the scroll wheel to scroll, not zoom. ![]() When thinking about user experience extremely common is not what you want in general. Hi think what users expect is heavily depending on the OS they are using (nomacs tries to bridge that). As a shield healer, Sage can easily shield themselves while playing solo, allowing them to be able to deal with damage that can otherwise kill them.Sage, despite being a healer, is still a battle job capable of dealing massive amounts of DPS and possesses a plethora of DPS skills that can be used to deal maximum damage to the enemies. Sage is a new healer job available in Final Fantasy XIV's latest expansion, Endwalker. Sage, one of the two new battle jobs available in Endwalker release. You want to use many different skills with flashy effects, and being able to use different sets of unique skills in one battle job.Therefore, being able to challenge yourself and collect all available Blue Mage skills excite you. ![]() You are looking to clear extremely old content very quickly, mainly ones from A Realm Reborn and Heavensward.They are also able to become either a Tank, Healer, or DPS as a Blue Mage, meaning this is a very versatile job that can defend, attack, and heal.The amount of skills they have allows them to be able to choose the skills they need into their set, adjusting to the old content they are clearing.This allows them to have a plethora of different skills. As a Blue Mage, players are able to learn the skills of their enemies upon seeing them cast or execute them, and then kill said enemy afterward.While this job has many limitations, including their level and the inability to enter the queue without premade parties, the benefits they provide make it worthwhile to play. This article will assist in listing 5 of the best jobs for this specific task, as well as explaining why.Ī Blue Mage is able to learn the skills of their enemies.īlue Mage is currently the only battle job that is capped at level 70 rather than 80, let alone 90, which is the new cap for all battle, crafter, and gatherer jobs in Endwalker. It is also worthwhile for people who have completed the MSQ and want to do something other than the raids and extreme trials in Endwalker.Īs a result, many players may be wondering which battle jobs are the best for soloing old content. While clearing old content may seem pointless and boring to some, many players continue to do so in order to obtain rare mounts, minions, and other specific items that can only be obtained by clearing old content. ![]() However, several players have decided to delve into old content as well, particularly those who have reached max level in their battle job and completed the Endwalker Main Scenario Questline. ![]() With the release of Endwalker's newest expansion, a large number of players have begun grinding on new content. 6/7/2023 0 Comments Verdun player countOur team of scientists and engineers transform innovative ideas into proven designs and high-quality products and components.Centris is a not-for-profit financial organization. It’s always smart to review your account activity and to call the number on the back of your card about unrecognized charges.From concept to production, Centrus Technical Solutions helps our customers reduce the time, cost, and risk of developing and manufacturing complex engineered products. Love words? You must - there are over 200,000 words in our free online dictionary, but you are looking for one that’s only in the …We continually monitor your account for fraudulent activity, including any merchant data breaches. Phone Number: (402) 334-7000 Toll-Free: (800) 334-2328 Mailing Address: Centris FCU 13120 Pierce Street Omaha, NE 68144 Website: The meaning of CENTRIES is plural of centry. It's the 2nd largest credit union in Nebraska with assets totaling $1.2 Billion and provides banking services to more than 126,000 members as of April 2023. GitHubCentris Federal Credit Union has been open since 1934.I accept GitHub: Where the world builds software ![]() By continuing to use this site, you acknowledge our privacy policy and our terms of use. Explore nearby Centris New Home Community - Miami - Miami, FL | Lennar This website uses cookies We use cookies in order to optimize our website and continually improve it. Among some of the top attractions in the area are LoanDepot Park, University of Miami and Dadeland Mall. North America Asia-Pacific Europe, Middle East & Africa Latin America & The Caribbean We are an Equal Opportunity Employer.Centris provides easy access to the best of Miami including proximity to The Falls, one of Miami’s premier shopping, entertainment and dining destinations. Serve Globally With locations in 18 countries around the world and work-at-home opportunities, you don't have to go far to be part of our team. LEARN MORE ABOUT OUR MEMBER BENEFITS CENTRIS IN THE COMMUNITY What does centris mean? Information and translations of centris in the most comprehensive dictionary definitions resource on the web. We don’t have stockholders, and any profits we make are turned back to our members in the form of lower rates on loans and higher rates on savings as well as improved products and services. I acceptCentris is a not-for-profit financial organization. ![]() The Largest Number of Homes for …Centris New Home Community - Miami - Miami, FL | Lennar This website uses cookies We use cookies in order to optimize our website and continually improve it. Find your house, condo, cottage, lot, plex, business. ![]() Centris.ca contains all of the properties for sale or for rent by real estate brokers in Québec. 6/7/2023 0 Comments Soik devil daggersIt was even pretty, in a way that holds up well 10 years later. It enjoyed the perfect combination of being absolutely massive in scope “it’s all of human history, and you’re driving it”, while presenting itself in a way that was intuitive and easily comprehensible - and not just by the benchmarks of the strategy genre. Nate: Despite having plenty of love for the games to either side in the series (Graham still reckons 2005’s Civ 4 is better), something about Civ 5’s iteration on uncle Sid’s original recipe, especially once it had all its DLC in place, was magic. As ever, Civ 5 was about taking a human population from the age of fistfights in sheds made of bone, right through to spaceman times, via the foundation and development of cities, the research of new technologies, and the knackering of other peoples’ cities through war. The first fresh civ game of the decade, 2010’s Civilization 5 - complete with its transformative Gods & Kings and Brave New World expansions - arguably set the high water mark for the series to date. I’ve not played it for many years but I remember all these names, their real characters, and the ones I made up. Having Wrex, the best character in the whole series, welcome me as his old friend, only made the whole thing more perfect. Then I did his loyalty mission, and in that short level he became the complex character such a huge storyline deserved. Shockingly, everyone loves Mordin and everyone loathes Miranda (jokes about Thane being a sex pest, Morinth and Jack being teenagers, or Grunt eating Jacob’s many pets were a mixed bag). Sin: Years before I invaded RPS, I made a novelty Twitter account that posted alternative endings to Mass Effect 3, which I still haven’t played. Mass Effect 2 made it feel alive, and made me realise why - and for who - I was fighting to save it. Reader, when Archangel took off their helmet, I nearly fell off my chair with joy.Īlice0: The first Mass Effect made the galaxy feel big. He told me to tell him when I got to the mission in Mass Effect 2 where you recruit the sniper Archangel, so he could sit in and watch my reaction. When I played Mass Effect, it was at the behest of my university housemate, who'd already played both. Maybe that's too much to ask of other games, though. But playing Mass Effect 2, in the very specific context of having played the first Mass Effect, was an experience that no other game has equalled since. The combat controls were a massive improvement on the original, and putting Shepard in the employ of a shady independent company gave an extra frisson to the Y/N moral choices you make in a Mass Effect game. A shooty squad action game rather than turn based fantasy, this middle instalment in Commander Shepard's epic sci-fi adventure provides you with aliens to smooch, friends to reunite with, and high concept shenanigans to have.Īlice Bee: Mass Effect 2 will always be the ultimate Mass Effect for me. Mass Effect is arguably the flagship of BioWare's "decisions in this game affect future ones!" brand of RPGs. Now, hop to the next page to begin the list. Please consider writing an impassioned celebration of your favourite game in the comments below, so that you might convince others to give it a try. Yes, even though this list is not numbered and is in chronological order. If your favourite game is not included, know that it is at number 51. ![]() This list is, ultimately, entirely subjective.Īnd yet objectively correct. We have done this because we prefer these games more. In some instances we have selected one of the games that followed in their footsteps. There are many groundbreaking games and genre progenitors from the past ten years that you will not find on this list. ![]() Many of the games in this list have phenomenal prequel or sequels, but we could only include so many games before our fingers grew tired from writing.įinally, we do not care about importance or influence. Our goal is to offer you a collection of great and diverse games, not to quibble over technicalities.įor this same reason, we have only picked one entry from each game series. ![]() We don't care if it's initial release was in the decade prior on console, or if it was released in Early Access or similar prior to 2010. First: if it was released on PC in the past decade, it is eligible for inclusion. Watch on YouTube 2010-2019: the decade's greatest PC gamesĪ few notes on the selection process before we begin. Whenever we try making something completely new it feels like a big gamble, so we’re really happy that the game has found an audience, and I hope that more people will enjoy it now that it’s arriving on PlayStation and Switch. “We’ve been around for 14 years now, and Nobody Saves the World has quickly become one of our most successful games. The announcement of Nobody Saves The World local co-op and April 14 release date for PS5, PS4, and Switch comes off the heels of its recent success: We’re really happy that the game has found. “It’s been great to see the game being received so positively by our existing fans as well as new players,” said Graham Smith, Producer on Nobody Saves the World and Co-Founder at Drinkbox Studios. Nobody Saves the World will support cross-gen co-op multiplayer on PlayStation, with PS5 and PS4 players being able to play online co-op with each other. On Nintendo Switch, players will even be able to save the world with a friend on the same Switch with a single Joy-Con in Tabletop Mode. Along with its release on Switch and PlayStation, Nobody Saves the World will receive a much requested local co-op update on all current platforms on the same day. Save data is tied to the console, and I dont think Nintendo can lock a. PlayStation players will get both the PS5 and PS4 versions for a single purchase price. I wonder if local co-op will be split screen, or the type of co-op were you both. Local & Online Co-op: Invite a friend to play through all, or part, of your adventure together Awesome Soundtrack: New original music by acclaimed composer Jim. (By the way, Kirby Star Allies is also fun with local co-op.) Nobody Saves the World Image: Drinkbox Studios Play as characters named Nobody as you work together to attempt to cure. It would be another mode that supports local multiplayer. ![]() “ Drinkbox Studios (Guacamelee!) are excited to finally announce that their latest game, Nobody Saves the World, will release on Nintendo Switch, PlayStation 5, and PlayStation 4 on April 14th for $24.99 USD, with pre-orders opening on Switch today with a 10% discount. Ultimates World Of Light Mode Will Not Include Co-Op Nintendo Life One against the world by. ![]() Nobody Saves the World is a game I’ll absolutely be talking about more at GOTY time, so if you haven’t been able to play it yet you should jump on this port. After setting the world on fire on Xbox and PC, now even more people will be able to enjoy its form changing gameplay. A fantastic game is coming to more consoles this month, as Nobody Saves the World arrives on Switch and PS4/PS5 on April 14th. ![]() I've tried both Legacy & UEFI boot loaders. Multibeast creates an EFI Drive that automatically mounts itself on to my desktop, but when I reboot (with USB) it disappears. The only way to boot into my system is to use the USB. When I click one of those boot options (the duplicate ones), it brings me to the clover boot loader but does not show any drives to boot from. So now I have over 10 boot options with the same name and function (none of which work). When loading my boot manager (F12), I notice that each time I reboot it adds a duplicate boot option. I've followed multiple different tutorials on how to fix this as this seems like it is a fairly common issue on the internet. Once the install was complete, my next step was to make the system bootable without the USB. I am using a Samsung 960 Pro NVME SSD for my install. ![]() I did successfully install MacOS Mojave using a bootable USB made with Unibeast. I've now come back around to the idea of installing MacOS and have actually had a good bit of success so far, but still haven't quite figured it all out. However similar to now, I was unsuccessful and decided to install Windows 10 instead. A few years ago I built this Desktop with the intentions to install MacOS. Hello everyone! I'm a little new to building a Hackintosh. Thanks to its intuitive design, finding your way around the Clover Configurator application is quite easy: simply navigate to the available sections and adjust specific parameters.Īs a result, Clover Configurator is a great tool to have around if you want to have a better control over your Clover EFI bootloader, without having to deal with complex commands and workflows.Building a CustoMac Hackintosh: Buyer's Guide Create your own Clover EFI config files via a streamlined and well organized graphical user interface When you are satisfied with your settings, navigate to the built in generator to create a config file that will provide an almost complete configuration file for your Clover EFI bootloader. The utility also streamlines certain tasks: you can mount the EFI drive, you can view and save the boot.log file, you can preview and change the Clover theme, or you can install 32bit, 64bit, or 64bit UEFI drivers. This utility keeps the Clover EFI parameters organized into various sections: you can start by modifying the ACPI parameters, you can personalize the boot mode, adjust the CPU performance, disable certain drivers, and so on. ![]() The Clover Configurator app is organized around two major functionalities: you can use the available tools to perform certain tasks, or you can customize certain parameters associated with the Clover EFI configuration file.Įffortlessly modify the parameters of your Clover EFI configuration file In addition, Clover Configurator can check for the latest Clover EFI revision, and helps you download and install the bootloader. Upon launch, Clover Configurator will check to see if there are already available configuration files, and enables you to view their content. Clover Configurator designed to help you create custom configuration files for the Clover EFI bootloader via a streamlined graphical interface.Ĭlover Configurator easy to install for generating Clover EFI configuration files 6/7/2023 0 Comments Backline rig 2![]() Quite unfair really since the exchange is only approx 126%. ![]() I noticed this and sent in a ticket upon seeing some RE's that are 145% conversion from USD to CAD. The Shop doesn't use dynamic currency exchanges - they are fixed (someone inputs the price / conversion factor for each currency). Get that a forum/group discount and take advantage of the exchange rates. Shame we can't buy REs and Bundles from places like JRR shop. UK price is 75 GBP which is a tad over 100 USD. Interesting to see that the US price for the upgrade is 79 USD. I have Synth Rigs 3 and I can access the upgrade to 4.Not that I'll be buying it - there is no value in the extra stuff for me but I will take a look at Rigs 5 if it ever arrives. I don't actually have the synth rig, but I do have the mix and master rig (first or second one, can't remember) and it says the same thing - not available this account. That's a really good answer, and should be the end of the discussion.Says 'not available for this account' for me, and clicking the link asks me to upgrade to a newer version of Reason, but I have the newest. Joey is humble and down to earth, I would recommend anybody that wonders about something he does, just ask him. One last thing, these type of modern instruments what will keep the organ sound and players lasting into infinity! " It's on his facebook fan page. Ive got gear in the Circle Ballroom for the ceremony, another small rig. Im confident if you keep an open mind and check them out, youll be understand why Id choose the Legend over a vintage tonewheel every time. Backline tech today for Element Music for a wedding in the iconic Venetian. 72 likes, 2 comments - Deluxe Guitars & Backline Hire (deluxeguitars) on Instagram: 'REDBEARD EFFECTS RED MIST MKIV In a market saturated with clones and reimagined tones, re. Try these instruments, or any other modern organ, to see for yourself. What I love most is you know what youre going to get when you play one, a beautiful consistent sound, with Everything working like it should. When I played and heard the Viscount Legend I realized we finally have a modern organ that has all the features were familiar with as well as incredible tone. Backline Rig 2: Boutique amps, rotary speakers, soulful keys and vintage effect units designed to transport a Reason rack to 1977. Ive always supported attempts in recreating the classic tonewheel sound. ![]() I just dont have the interest in repairing somebody elses organ at sound check anymore. From pedals not working or sticking, Percussion not decaying, Vibrato not working, harmonics not playing, drawbars out, or just not a good sounding organ. No matter how good the organ works, theres always something that can go wrong. And almost all of these Instruments, with the exception of a very few, have some sort of problem. And in many cases Ive had to use gear provided by a backline company. And though I own several primo condition examples of them, they are very difficult to travel with and maintain. Lets remember the last one was made in 1975. Can you divulge your reasons so we can end the mind reading session, Thanks!" And Joey answered back this:"Joey DeFrancesco - Fan Page Let me start by saying my love for the Vintage Hammond Tonewheel Organs will always be. I suggested asking you, and I got nominated to do it. So I did, "Joey, there's a long thread on one of the hammond groups about why you went with the lebend instead of a hammond b3 at the Chris Botti special on pbs. They told me since it was my idea I should. I opened my big mouth and said why doesn't someone ask him. A while aback on a facebook group we had a discussion about this same question raised here. ![]() Sign-in with your credentials and allow the ShuttleCloud app to access your Gmail and Google contacts data. In the pop-up window, specify the email address of your existing account from where you wish to import the messages into the new account. There are no addons to install and the Gmail-to-Gmail transfer happens directly in the cloud.Ĭreate a new Gmail account for backup, go to Settings, select the Accounts and Import tab and choose Import Mail and Contacts. If your current Gmail account is running low on storage, you can consider using a new Gmail account to backup your existing emails and then delete the bulky mails from the primary account to make space. Move Gmail Data from One Google Account to Another ![]() So if you archive an email thread that contains, say, a 10 MB file attachment, the email will end up consuming 20 MB overall space in your Google Storage (10 MB in Gmail and another 10 MB in Drive). The little downside with this approach is that Gmail and Google Drive share common storage space. ![]() You can then use the Drive client to backup the files saved in Drive to your local Windows PC or Mac. Looking for an easy way to backup your Gmail messages? The Download Gmail add-on automatically saves a copy of your Gmail emails and file attachments to your Google Drive. 6/7/2023 0 Comments Coptic sunrise music math rockFor a glimpse of what the future of math rock may sound like, you should go listen to black midi’s inventive album “ Schlagenheim. If you want to continue to explore the best math rock has to offer, please check out bands like Delta Sleep, Covet, Totorro, 65daysofstatic, Hella, Minus the Bear, Cap’n Jazz, Marnie Stern, and Lightning Bolt. Hopefully, the future will continue to present us with terrific math rock bands that can bring something new and innovative to the table.įinally, I believe it’s important to add some honorable mentions to the list, as many top-tier math rock acts were sadly left out of the top 10. Ever since pioneers such as Drive Like Jehu and Slint decided to incorporate sophisticated musical notions into their in-your-face post-hardcore music, the subgenre has evolved in multiple directions, dragging influences from all territories of music.Īny list of the 10 best bands of math rock of all time is certainly subjective, but this one covers the evolution of the style from its very beginning to the present day. Math rock is a subgenre that’s existed since the late ’80s but only matured in the mid-‘2000s. Led by the bassist/singer Henry Tremain, TTNG surprised their fans in 2018, with the release of “Animals Acoustic,” an acoustic album inspired by their seminal 2008 record “Animals.” That’s how good TTNG’s songs are: they can stand tall even without all the flourishing that characterizes most math rock music. In other words, they’re an emo band capable of pleasing both music experts and angsty teenagers. They’re probably the most beloved math rock band coming from the United Kingdom, and their music is a finely-balanced combination of math rock and emo music.įormed in 2004 and still active today, TTNG are emo in their core but work like a breath of fresh air in the genre due to their incorporation of math rock riffs and rhythms. ShellacĪ list of the best math rock bands of all time couldn’t be complete without This Town Needs Guns, best known as TTNG. Below, you can find the 10 best math-rock bands of all time. Because most math rock songs feature complex arrangements, the subgenre is also known for its wall-of-sound sonority.Ī type of music made for die-hard rock fans, math rock evolved a lot since it first appeared in the late ’80s, drawing in a series of influences from musical spectrums as disparate as metal, jazz, and electronic music. While math rock bands sound very different from one another, they’re all based on the same core principles: to explore new song structures and techniques in rock, no matter how strange or complicated. It combines influences from indie rock, post-hardcore, prog rock, and post-rock.Ĭreated in the late ’80s and popularized in the two following decades, “math rock” was named as such due to its quasi-mathematical rhythmic complexity. While many math rock bands feature vocals, the subgenre is mostly instrumental. Excerpt from A Voyage to Arcturus, by David Lindsay.Math rock is a subgenre based on complex guitar riffs, unusual harmonies, abrupt changes in style and tempo, and odd time signatures. The roots were revolving, for each small plant in the whole patch, like the spokes of a rimless wheel. Also, the style is a little more rockist than post-rock. Where post-rock has distinct jazz influences, math rock is the opposite side of the same coin - its dense and complex, filled with difficult time signatures and intertwining phrases. When it came near enough he perceived that it was not grass there were no blades, but only purple roots. Math Rock is a relation to post-rock, a better known indie-rock style that shares similar aesthetics. When it came near enough he perceived that it was not grass there were no blades, but only purple roots. What looked like a small patch of purple grass, above five feet square, was moving across the sand in their direction. Tim Brown’s Modular Scale site raised awareness about type scales, helped to improve typography on the web, and it was the inspiration for this project. You can read more about these units from an article I wrote on the subject, Confused About REM and EM? Additional Resources The only difference between the two is that em is proportionate to its nearest parent that has a font-size, whereas rem is always relative to The em value is the same as the rem value displayed above. Large scales (1.333 or greater) may be challenging to implement effectively, but could work well for portfolios, agencies, some marketing sites, or avant-garde works. A medium scale is versatile and works well for a wide variety of desktop sites, including blogs and ![]() ![]() Medium scales (1.15–1.333) have a clear hierarchy, and help to organize sections with subheadings. Small scales (less than 1.2) are subtle and good for both mobile and desktop apps, or the mobile version of a responsive site. |